Molecular synthesis based on radical formation by direct photoexcitation of boron-ate complex

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06474
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
• Research Institution: Tokyo Medical and Dental University (2023); Kanazawa University (2021-2022)
• Principal Investigator: Sumida Yuto 東京医科歯科大学, 生体材料工学研究所, 准教授 (40630976)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 有機ホウ素アート錯体 / 光反応 / ラジカル反応

Outline of Final Research Achievements

The aim of this study was to develop an exhaustive organic radical generation method by direct excitation and to achieve highly challenging molecular transformations using this method. In particular, by using boron-ate complexes prepared from boracene, organic radical generation by direct excitation with visible light, which was previously difficult, was achieved. The resultant system also enables highly efficient conversion of a wide variety of organic molecules. This methodology provides straightforward chemical transformations that do not rely on conventional photocatalysis and pioneers the basis for new methods in photosynthetic chemistry. The results of this research will contribute significantly to a wide range of fields, including organic synthesis, drug discovery science, chemical biology and materials science.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、直接励起による有機ラジカル発生法という新たな化学手法を確立し、高難度な分子変換を実現した点にある。これにより、従来の熱的経路では困難であった反応様式を可能にし、有機合成の新たな可能性を切り拓いた。また、社会的意義としては、この新手法が創薬や材料科学などの分野での応用展開を見据えたものである点が挙げられる。特に、光触媒を必要としないため、コストや環境負荷の低減にも寄与する。本研究成果は、持続可能な化学プロセスの開発に貢献し、将来的には産業界での実用化も期待される。