2023 Fiscal Year Final Research Report
Study of the antimicrobial dosage in consideration of hemofilter membranes properties under the CHDF
| Project/Area Number |
21K06686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | CHDF / 抗菌薬 / AN69ST / PMMA |
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| Outline of Final Research Achievements |
AN69ST membrane hemofilters have a high adsorption ability for cytokines, but concerns exist regarding their ad- sorption and removal abilities for antibiotics to use for treatment. Therefore, we examined the effect of the adsorp- tion of meropenem(MEPM), pazufloxacin(PZFX), cefozopran(CZOP), vancomycin(VCM), and teicoplanin(TEIC) onto AN69ST membranes via in vitro experiments. The adsorption ability was evaluated by measuring the absor- bance of each antibiotic solution added to the AN69ST membranes over time. We observed that the content rates of TEIC, PZFX, and VCM decreased compared with those of the solution that was not added to the AN69ST mem- branes;however, the content rates of MEPM and CZOP showed no decrease. Therefore, our results suggest that TEIC, PZFX, and VCM were adsorbed and removed by the AN69ST membranes. Thus, while using AN69ST mem- branes, it is crucial to set the antibiotic dose for administration by considering the decrease in the blood level.
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| Free Research Field |
医療薬学
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| Academic Significance and Societal Importance of the Research Achievements |
AN69ST膜の開発の元となった AN69膜に対する薬剤の吸着については、過去に一部の薬剤に対して検討されているものの、そのほとんどが CHDF の施行と同時に使用する可能性の低い薬剤であった。急性期医療において臨床ニーズの高い薬剤においてAN69ST膜に対する吸着挙動を検討することは、急性期チーム医療における薬剤師としての責務でもあると考える。これまでは AN69ST膜HFによる CHDF を行う際の抗菌薬の至適投与量の設定に苦慮していたが、本研究により AN69ST膜に対する抗菌薬の吸着の影響が明らかになれば、至適投与量を推定することにつながり、患者の治療に大きく貢献できると考える。
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