2023 Fiscal Year Final Research Report
Development of a novel lung adenocarcinoma treatment targeting autophagic cell death
Project/Area Number |
21K06691
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 47060:Clinical pharmacy-related
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Research Institution | University of Miyazaki |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
池田 龍二 宮崎大学, 医学部, 教授 (50398278)
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Keywords | オートファジー / 肺腺癌 / 腫瘍抑制因子 |
Outline of Final Research Achievements |
In this study, we aimed to clarify the mechanism by which BHLHE41 induces autophagic cell death. Expressed BHLHE41 decreased the expression of Bax, Bcl2, and BNIP3. Since the decreased expression of Bcl2 is involved in autophagy, it was suggested that the decreased expression of Bcl2 is involved in autophagic cell death induced by BHLHE41. Expression of BHLHE41 also decreased the expression of the ferroptosis inhibitor AIFM2 and induced ferroptosis. In addition to autophagic cell death, BHLHE41 is also thought to induce ferroptosis. Since autophagy is also associated with ferroptosis, we plan to analyze the detailed mechanism of autophagy in the future.
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Free Research Field |
分子腫瘍学
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Academic Significance and Societal Importance of the Research Achievements |
BHLHE41は肺腺癌において悪性化進展においてオートファジー細胞死を誘導し腫瘍抑制的に働くことを明らかにしている。 BHLHE41の発現時にオートファジーの抑制に関わるBcl2の発現減少することからオートファジー誘導に関わっていることが示唆された。また、同時期にフェロトーシスも起こっていることが明らかになった。このBHLHE41のオートファジー細胞死の誘導メカニズムが分かれば新規肺腺癌治療薬の開発に繋がることが考えられる。
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