Effects of short-term use of Goreisan on migraine caused by weather changes and analysis of non-responsive cases

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06693
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Teikyo Heisei University
• Principal Investigator: Ishii Masakazu 帝京平成大学, 薬学部, 教授 (30307061)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 片頭痛 / 五苓散 / 天候 / 予兆期 / 治療抵抗性

Outline of Final Research Achievements

To investigate clinical factors affecting Goreisan therapy from the premonitory period in migraine patients with weather-induced headache and establish a scoring system for predicting a negative response to Goreisan. We examined clinical factors of consistent responders (CRs) and inconsistent responders (IRs) to Goreisan therapy from the premonitory period. Past histories of psychiatric disorders and insomnia were significant factors that independently contributed to a negative response. Odds ratios of psychiatric disorders and insomnia were 10.549 (yes vs. no), and 3.049 (yes vs. no), respectively. The predictive index (PI) of the negative response to Goreisan therapy from the premonitory period in migraine patients with weather-induced headache was calculated using the regression coefficients of these two factors. PI was significantly higher for IRs than CRs (p < 0.001). The obtained PI may represent an appropriate scoring system for negative responses to Goreisan therapy.

Free Research Field

薬学

Academic Significance and Societal Importance of the Research Achievements

漢方薬は経験的に使用され発展してきた治療薬であるため、科学的なエビデンスが不足している。本研究成果は五苓散を使用した頭痛治療のエビデンスのひとつとなることが期待される。また、天候（気圧）の変化によって頭痛を発症する片頭痛患者において、予兆期からの五苓散の服用で治療を行う際に、事前に効果があるか否かを予測することを可能とした。本邦では、五苓散は処方薬だけでなく、市販薬として薬局でも販売していることから、薬剤師が頭痛患者に五苓散を提案・販売する際にも、有用なツールとなることが期待される。