2023 Fiscal Year Final Research Report
Identification of inflammation suppressive DAMPs and their pathophysiological significance in inflammatory diseases
| Project/Area Number |
21K06701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Shujitsu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
豊村 隆男 就実大学, 薬学部, 准教授 (40425137)
森 秀治 就実大学, 薬学部, 教授 (50220009)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ダメージ関連分子パターン / DAMPs / HMGB1 / LPS / リボソームタンパク質 / 終末糖化産物 / AGEs |
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| Outline of Final Research Achievements |
Recently, it has been revealed that biomolecules (damage-associated molecular patterns: DAMPs) that have migrated to different locations from their original sites in the body due to various factors induce inflammation. DAMPs may cause diseases such as diabetes, age-related changes in physiological functions, and cancer, which are believed to be caused by lifestyle-related factors. In this study, we demonstrated the existence of molecules that appear by a mechanism similar to that of DAMPs and inhibit the action of DAMPs (suppressive DAMPs).
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| Free Research Field |
医療薬学
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| Academic Significance and Societal Importance of the Research Achievements |
DAMPsが種々の慢性炎症が原因となる疾患の要因となる可能性は既に指摘され，DAMPsを標的とした新規疾患治療法が模索されている．本研究では，生体内にDAMPsと対になって炎症を制御するメカニズム（抑制性DAMPs）が存在する可能性を示した．抑制性DAMPsの発見は，DAMPsによる炎症反応を制御するメカニズムに新たな知見を追加することのみならず，DAMPsを標的とした治療法を考える上で，新たな標的となる可能性を有しており，今後の新規治療法の開発や創薬に寄与することが期待できる．
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