2023 Fiscal Year Final Research Report
Analysis of molecular mechanism of parabronchial lymphoid tissue (BALT) based on the Wnt signal pathway
| Project/Area Number |
21K06755
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 48010:Anatomy-related
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | BALT / Wntシグナル / 組織系譜解析 / リンパ組織 |
|---|
| Outline of Final Research Achievements |
BALT (bronchus-associated lymphoid tissue) is a lymphoid tissue that functions as the keystone of airway immune defense against inhalable foreign substances. However,it is only known that it manifests in the bronchiole region of the lungs due to antigen stimulation, and the understanding at the molecular level is still insufficient. Also, excessive BALT makes some airway diseases.We identified the Wnt signal as a signal pathway that promotes BALT, and found that its excessive hyperactivity strongly promotes the development of BALT. We investigated (1) the molecular mechanism of action when BALT manifests in the lungs, and (2) the clinical significance and role of manifested BALT in human respiratory diseases through analysis centered on Wnt signals.
|
| Free Research Field |
組織学、病理学
|
| Academic Significance and Societal Importance of the Research Achievements |
気道免疫の主体をなすBALTの発生機序を完全に解明することは、呼吸器系でBALTを自由自在に顕在化させることで粘膜面での免疫防御を最大限に強化し、外来異物の侵入・感染に備えるという予防としての先制医療戦略の確立につながる。新型肺炎の世界的な蔓延は記憶に新しいが、呼吸器感染症に対する有効な対抗手段の重要性や必要性が再認識される中、本研究課題の成果が医学的恩恵を社会にもたらす可能性は十分に考えられる。
|
