Role of CHP3 in heart failure induced by diabetes

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06774
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48020:Physiology-related
• Research Institution: Showa University
• Principal Investigator: Kobayashi Soushi 昭和大学, 薬学部, 講師 (50511531)
• Co-Investigator(Kenkyū-buntansha): 野部 浩司 昭和大学, 薬学部, 教授 (30276612) ; 柴田 佳太 昭和大学, 薬学部, 准教授 (50727328)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: CHP3 / 心筋細胞 / 骨格筋細胞

Outline of Final Research Achievements

CHP3 is one of the proteins with unknown function. Previously, CHP3 was found to regulate cardiomyocyte volume via insulin signaling. In this study, we aimed to determine the effects of CHP3 on the formation of cardiac hypertrophy in obesity and type 2 diabetes mellitus. CHP3-deficient mice were found to gain weight and heart weight with aging. In addition, CHP3-deficient mice at 48 weeks of age had increased blood glucose levels after glucose loading compared to wild-type mice. Furthermore, rectus femoris and soleus muscle weights were reduced, and muscle strength was also decreased. Thus, it was suggested that CHP3 deficiency causes abnormal glucose metabolism via skeletal muscle loss, resulting in cardiac hypertrophy.

Free Research Field

生理学

Academic Significance and Societal Importance of the Research Achievements

現在、高インスリン血症による心肥大の発症を抑制する方法は確立されていない。本研究ではCHP3の機能を明らかにすることで、肥満や糖尿病由来の心肥大を抑制する方法の開発に貢献できると考えられる。