Analysis for heterogeneity of cancer genome profile

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06895
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Keio University
• Principal Investigator: Aimono Eriko 慶應義塾大学, 医学部(信濃町), 特任助教 (90835638)
• Co-Investigator(Kenkyū-buntansha): 西原 広史 慶應義塾大学, 医学部(信濃町), 教授 (50322805)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: シークエンス / 遺伝子プロファイル / Heterogeneity

Outline of Final Research Achievements

We analyzed the spatial-temporal multiple cancer samples from 31 cancer patients and compared the genomic profile. The genomic profiles of multi-primary cancer were completely different, while the genomic profile between the primary tissue and metastasized tissue was similar except the several treatment-related drug response gene. About the spatial heterogeneity, the genomic profile was almost identical, meaning that it is not necessary to perform the multiple sequence for molecular diagnosis.

Free Research Field

臨床病理学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果、がんの分子診断を行うために、どのようなときに複数検体でのシークエンスが必要なのか、方向性を示すことが出来た。このことにより、不要なシークエンス費用を抑え、最適ながんゲノム医療の推進に有用な情報を提供することができた。