2023 Fiscal Year Final Research Report
Hyperexpression of MYC gene in early onset breast cancer: Contribution of a transcriptional factor E2F5
| Project/Area Number |
21K06915
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
坂東 裕子 筑波大学, 医学医療系, 准教授 (00400680)
清水 千佳子 国立研究開発法人国立国際医療研究センター, その他部局等, 乳腺・腫瘍内科 診療科長 (10399462)
渡邊 知映 昭和大学, 保健医療学部, 教授 (20425432)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 年性乳癌 / MYC / E2F5 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify whether MYC overexpression contributes to carcinogenesis of young onset breast cancer (AYA breast cancer), the frequency of MYC gene amplification, and activation of cell proliferation/cell cycle pathways. Clinicopathological study and gene expression analysis using RNA sequencing were performed. The proportion of c-MYC IHC positive cases was significantly higher in the AYA group. Especially, in non-AYA group, the proportion of c-MYC IHC positive cases was significantly higher in the high-grade group (high nuclear grade, high histological grade, Ki-67 positivity rate ≧20%, triple-negative breast cancer). MYC amplification was detected in 11.9% of the cases of the AYA group, and 8.2% of the non-AYA group.
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| Free Research Field |
人体病理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、AYA群でc-MYC IHC陽性症例割合が有意に高いことが明らかになった。また、non-AYA群おいては、高悪性度群(高核異型度、高組織学的異型度、Ki-67陽性率 ≧20%、トリプルネガティブ乳癌)で、c-MYC IHC陽性症例割合が有意に高いことが明らかになった。これらの結果からは、AYA群がnon-AYA群に比較して予後不良であること、またnon-AYA群の予後不良因子の一つとしての可能性、ならびに今後の研究の方向性が示された。
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