Difference in genome imprinting between mature and immature ovarian teratomas

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Hirosaki University
• Principal Investigator: Kato Noriko 弘前大学, 保健学研究科, 教授 (40312730)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 卵巣奇形腫 / ゲノムインプリンティング

Outline of Final Research Achievements

Ovarian teratomas contain only maternal genomes. Concordantly, mature ovarian teratomas show maternal methylation pattern of imprinted genes. In the present study, methylation profile of imprinted genes was investigated in a series of immature ovarian teratomas. Overall, immature ovarian teratomas showed maternal methylation pattern of imprinted genes. However, they also showed aberrant methylation levels in a few imprinted genes. These findings suggest that genome imprinting in immature teratomas partially differs from that in mature teratomas.

Free Research Field

人体病理学

Academic Significance and Societal Importance of the Research Achievements

卵巣未熟奇形腫はES/iPS細胞を免疫不全マウスに移植した時にできる奇形腫と組織学的に類似する。ES/iPS細胞を用いた再生医療では、移植細胞のゲノム・エピゲノムの不安定性および腫瘍化のリスクを伴い、奇形腫の形成はその代表である。今回、卵巣未熟奇形腫で得られた知見は、ES/iPS細胞由来の奇形腫におけるエピゲノム異常を解明し、その制御を目指すうえでの基礎的データとなる。