Establishment of the procedure to regulate artificially the neural vascular barrier function for overcoming the intractability of neural diseases

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06949
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49030:Experimental pathology-related
• Research Institution: Yamaguchi University
• Principal Investigator: Ikeda Eiji 山口大学, 大学院医学系研究科, 教授 (30232177)
• Co-Investigator(Kenkyū-buntansha): 崔 丹 山口大学, 大学院医学系研究科, 准教授 (40346549)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 血液脳関門 / 脳血管内皮細胞 / Basigin / 難治性神経疾患 / 高マンノース型糖鎖

Outline of Final Research Achievements

In the present study, an aspect of the mechanisms underlying the involvement of basigin with high-mannose-type glycan in the pathological opening of neural vascular barrier was clarified. Furthermore, with the animal models with pathological opening of neural vascular barrier, basigin with high mannose-type glycan was shown to be available as the specific target for prevention as well as treatment against the pathological opening of neural vascular barrier. As for the artificial opening of neural vascular barrier through stimulation of basigin, the findings which had been obtained by experiments with mice were reproduced with human cells, and therefore the stage of drug development was started.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

神経系血管バリアーが病的に‘開いた状態’になることが病態悪化の中枢を担う神経疾患が多く存在する。また一方では、神経系血管バリアーの存在（‘閉じた状態’）は全身投与した治療薬が神経組織実質に到達できず治療の妨げになる側面も有している。したがって、現在の医療が有していない神経系血管バリアーの人為的制御手法（‘閉じた状態’⇔‘開いた状態’）の確立に繋がる本研究成果の臨床現場への展開により、神経疾患の治療に大きな変革がもたらされ、多くの神経疾患の難治性克服が期待される。