2023 Fiscal Year Final Research Report

Investigation of the cause of mental illnesses using model mice with early-life and adolescent stress

Research Project

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Project/Area Number	21K07343
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52010:General internal medicine-related
Research Institution	Kobe Pharmaceutical University
Principal Investigator	ATAKA KOJI 神戸薬科大学, 薬学部, 特任助教 (30563358)
Co-Investigator(Kenkyū-buntansha)	富原一哉鹿児島大学, 法文教育学域法文学系, 教授 (00272146) 浅川明弘鹿児島大学, 医歯学域医学系, 教授 (10452947) 岩井治樹鹿児島大学, 医歯学域歯学系, 助教 (30452949)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	いじめ / 摂食関連ペプチド / 攻撃性惹起 / いじめ被害者 / いじめ加害者 / うつ
Outline of Final Research Achievements	The bullied mice were divided into a resilience group and a susceptible group to aggressive mice, and a significant difference in food intake was observed between the two groups. Changes in depressive-like behavior and social behavior were observed in both groups. Regarding the expression of feeding-related peptides in the hypothalamus, 5 factors were significantly changed in the resistant group and 4 factors were significantly changed in the vulnerable group. In aggressive mice, food intake changed and depression-like and anxiety-like behaviors were observed. Six factors were altered in the expression of feeding-related peptides in the hypothalamus, and intracerebroventricular administration of their agonists or antagonists improved aggression, depression-like behavior, and anxiety-like behavior. Changes in food intake, anxiety-like behavior, and changes in bone marrow-derived cells were observed in mice subjected to psychological stress.
Free Research Field	心身症、薬理学、動物行動評価
Academic Significance and Societal Importance of the Research Achievements	本研究において、攻撃性マウスにおいて、視床下部の摂食関連ペプチドと攻撃性、不安、うつとは関連しており、摂食関連ペプチド受容体拮抗薬または作用薬でこれらの心身症状を改善できることが示唆できた。いじめや通り魔などの暴力行為について摂食関連ペプチドを標的とした治療戦略を構築できる可能性がある。いじめを受けるマウスにおいては、脆弱性を示す場合にのみ摂食量が変化し、脆弱性群、耐性群の両方で、うつ様行動、摂食関連ペプチドの変容が認められた。さらなる研究が必要ではあるが、いじめによる心身症と摂食関連ペプチドには関連性があり、攻撃性と同様に、摂食関連ペプチドを標的とした治療戦略を提案できる可能性がある。