the usefulness of baroreflex sensitivity in predicting recurrence after catheter ablation for atrial fibrillation

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07371
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Oita University
• Principal Investigator: Miyoshi Miho 大分大学, 医学部, 病院特任助教 (40873477)
• Co-Investigator(Kenkyū-buntansha): 近藤 秀和 大分大学, 医学部, 助教 (90724170)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: Baroreflex sensitivity

Outline of Final Research Achievements

A prospective observational study was conducted by enrolling 67 patients with atrial fibrillation who underwent ablation for atrial fibrillation in our hospital. Basic information, patient background, and various laboratory findings were collected at admission, and BRS was measured and compared at baseline and 2 days after ablation. Results: (1) The baseline value of BRS in patients with PeAF was significantly lower than that in patients with PAF; (2) BRS was significantly and dramatically; depressed after CA irrespective the type of AF; (3) The decrease in BRS because of CA appeared more prominent in patients with PAF as compared with the patients with PeAF; and (4) Amiodarone did not significantly affect the baseline BRS value, but it tended to improve the BRS.

Free Research Field

循環器

Academic Significance and Societal Importance of the Research Achievements

依然として高い再発率を示す持続性心房細動に対するアブレーション治療であるが，BRSの変化がアブレーション治療の有効性が高い患者群の同定につながる可能性がある。そのことから，ベースラインのBRSが低値でアブレーション治療の効果が低い, 再発率が高いと考えられる患者には薬物治療によるrate controlの方針を検討することで, アブレーションによる合併症や,医療コストの低減につながる可能性があると考える。