2023 Fiscal Year Final Research Report

Iodine intake of preterm infants

Research Project

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Project/Area Number	21K07393
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52010:General internal medicine-related
Research Institution	Wakayama Medical University
Principal Investigator	Tsuchihashi Tomoya 和歌山県立医科大学, 医学部, 助教 (20828488)
Co-Investigator(Kenkyū-buntansha)	鈴木崇之和歌山県立医科大学, 医学部, 助教 (40816691) 末永智浩和歌山県立医科大学, 医学部, 講師 (70433365) 垣本信幸和歌山県立医科大学, 医学部, 助教 (90614412) 熊谷健和歌山県立医科大学, 医学部, 講師 (60316114)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	ヨウ素 / 母乳中ヨウ素濃度 / 早産児
Outline of Final Research Achievements	Fifty-two preterm infants were enrolled in the study. The urinary iodine concentration of the preterm infants was 214ug/L, and no case showed abnormal thyroid function. The mother's urinary iodine concentration was 116.5 ug/L, and the same-day breast milk iodine concentration was 94 ug/L. There was a weak correlation between urinary and breast milk iodine concentrations (R2=0.3726). Comparing the fully artificially-fed and breast-fed infants, the urinary iodine concentrations were 128 ug/L and 287 ug/L, with the fully artificially-fed infants having significantly lower urinary iodine concentrations. The fully artificially fed infants were more preterm and had lower birth weight), and the more severe the preterm birth, the lower the urinary iodine concentration, which was thought to be related to the increased proportion of fully artificially fed infants.
Free Research Field	新生児
Academic Significance and Societal Importance of the Research Achievements	日本ではヨウ素過剰摂取国であるが、母乳ヨウ素濃度を測定した報告はほとんどなかった。また、乳児用ミルクに関してはヨウ素を添加しておらず、乳幼児、特に甲状腺機能が未熟な早産児においてヨウ素摂取量と甲状腺機能の関係は分かっていなかった。今回の研究では早産児におけるヨウ素耐容上限量を推定することは出来なかったが、日本人女性における平均的な母乳中ヨウ素濃度を示し、早産児におけるヨウ素摂取量の現状を明らかとすることができた。特に重度の早産児では母乳不足によるヨウ素摂取量が不足傾向にあることが分かり、今後の早産児管理で啓発していく必要性を明らかとすることができた。