2023 Fiscal Year Final Research Report
Enhancement of neual circuit remodeling by non-neuronal cells after central nervous system injury
| Project/Area Number |
21K07459
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 52020:Neurology-related
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
Itokazu Takahide 大阪大学, 大学院医学系研究科, 特任教授(常勤) (60750015)
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | 神経回路再編成 / 神経可塑性 / 脊髄損傷 / 機能回復 |
|---|
| Outline of Final Research Achievements |
After central nervous tissue damage,the local environment in the injured spinal cord is inhospitable for neural recovery and regeneration.Thus,therapies that can modulate scar formation and provide a growth-permissive environment are awaited.We investigated the possible involvement of ependymal cells and repair Schwann cells,which proliferate and migrate into the lesion after spinal cord injury.We elucidated novel molecular mechanisms that enhance proliferation and migration of these cells.Further,we revealed that pharmachological/genetic manupulation of these factors effectively enhanced neural circuit remodeling and functional recovery.
|
| Free Research Field |
病態神経科学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究により、上衣細胞やシュワン細胞といった中枢神経の辺縁に存在する細胞が中枢神経損傷に応答して増殖し、障害部位に集積すること、また同部位で神経栄養因子の分泌等を介して神経再生にとって有利な中枢環境を構築し、神経機能回復に寄与することを見出した。さらに同現象を促進可能な分子標的を見出すことが出来た。本知見は、神経機能再生治療に新たな選択肢を与えるものである。
|
