2023 Fiscal Year Final Research Report
The relationship between schizophrenia and sleep apnea and the effect of sleep-disordered breathing on improving psychiatric symptoms by treatment of sleep-disordered breathing
| Project/Area Number |
21K07537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
橋岡 禎征 旭川医科大学, 医学部, 教授 (00622523)
吉澤 門土 旭川医科大学, 医学部, 助教 (00516106)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | REM睡眠行動障害 / ビデオポリソムノグラフィ |
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| Outline of Final Research Achievements |
We performed video polysomnography to determine a predictable index for the severity of REM sleep behavior disorder (RBD) and the severity of the physical movement episodes. RBD episodes (RBDEs) in patients with RBD were classified according to their severity into the following three motor events (MEs): ME 1; small movements or thrusts; ME 2; proximal movements including violent acts; ME 3; axial movements including bed falls. For each ME, the number of MEs that were preceded by both RWA (REM sleep without Atonia) and REM sleep in the 10 seconds immediately preceding the onset of ME and the number of MEs that were not preceded by both RWA and REM sleep were measured. In severe RBDE (ME 3), the number of MEs preceded by both RWA and REMs was significantly higher than that of MEs not preceded by both (0.8 vs. 0.2, P = 0.033). This was not the case for mild RBDE (ME 1) and moderate RBDE (ME 2). Our results suggest that both RWA and REMs are associated with the development of severe RBDE.
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| Free Research Field |
睡眠医学
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| Academic Significance and Societal Importance of the Research Achievements |
睡眠時呼吸障害、ひいてはREM睡眠行動障害が精神疾患と密接な関連があることを実証することができた。
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