Imaging Asessment of Bone Pain

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07668
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Tateishi Ukihide 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20415524)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: TRPV1

Outline of Final Research Achievements

In order to objectively evaluate the presence of bone pain and cancer, we used a mouse animal model to perform imaging using a newly synthesized PET probe as a TRPV1-specific ligand, and compared it with conventional objective indicators. did. We synthesized a large number of TRPV1-specific ligands and imaged them starting from the one with the highest affinity. PET probe tumor-bearing mice were prepared with a number of solid carcinomas confirmed to overexpress TRPV1, PET images were taken, and the accumulation patterns and TRPV1 expression levels were compared. We compared the changes in TRPV1 expression status in the lesion using immunohistochemical staining and RNA distribution, and confirmed a good correlation. Based on these results, an international conference presentation and an English paper were published.

Free Research Field

放射線医学

Academic Significance and Societal Importance of the Research Achievements

この研究で特定したTRPV1 PETプローブは骨痛（Bone pain）や癌の存在診断の客観的評価よる視覚導入を行うことが可能と考えられ、従来の非客観的評価方法と比較することで疼痛発現や治療効果をより正確に実施できる。研究代表者らはこれまで難治性疾患の解明のために新規PET製剤による薬効評価方法論を構築し、繰り返し画像化してきた。また、悪性腫瘍に関しては低酸素状態での微小環境について機能画像法の開発を実施し、画像評価系の構築に成功した。こうした実績を踏まえ、TRPV1受容体イメージングによる骨痛や癌の存在診断の客観的評価の確立に役立つという点で社会的意義は大きい。