2023 Fiscal Year Final Research Report

An Imaging Biomarker Predicting Physical Inactivity in Chronic Obstructive Pulmonary Disease

Research Project

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Project/Area Number	21K07675
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52040:Radiological sciences-related
Research Institution	Yamaguchi University
Principal Investigator	Murata Yoriyuki 山口大学, 医学部附属病院, 助教 (30896824)
Co-Investigator(Kenkyū-buntansha)	平野綱彦山口大学, 医学部附属病院, 准教授 (00382333) 松永和人山口大学, 大学院医学系研究科, 教授 (20347602) 椎木健裕山口大学, 医学部附属病院, 講師 (30610456) 矢野雅文山口大学, 大学院医学系研究科, 教授 (90294628) 平野靖山口大学, 医学部附属病院, 准教授 (90324459) 間普真吾山口大学, 大学院創成科学研究科, 教授 (70434321)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	COPD / 身体活動性低下 / density analysis / E/I MLD
Outline of Final Research Achievements	Physical inactivity correlates with poor prognosis in COPD. We investigated the relationship between density analysis using inhalation and exhalation CT and physical activity in 41 COPD patients and 12 healthy subjects aged 40 years or older who visited Yamaguchi University Hospital. COPD patients had lower physical activity levels compared to healthy subjects, otherwise had higher E/I (expiratory to inspiratory ratio) values calculated by density analysis. Physical activity levels and E/I values showed a negative correlation. Among COPD patients, the physical inactivity group (14 patients) had a higher E/I values than the maintained physical activity group (27 patients), and E/I values was possible to predict physical inactivity independently of age, symptoms, and pulmonary function test. These results showed that E/I is an imaging biomarker that predicts physical inactivity in COPD patients.
Free Research Field	COPD
Academic Significance and Societal Importance of the Research Achievements	慢性閉塞性肺疾患（COPD）の患者は本邦でも潜在的に530万人いると推測されており，身体活動性低下はその予後を悪化させる要因である．しかし活動性が低下する機序はまだはっきりしておらず，さらに実際の医療現場で身体活動量を評価することは容易ではない．本研究では，吸気と呼気のCTを用いたdensity analysisが，COPD患者における身体活動性低下を予測しうるツールであることを証明した．このツールを用いることで，COPD患者の身体活動性低下を早期に発見できるとともに，身体活動性低下を生じさせる機序の解明につなげ，新たな治療方法の確立に結び付けることが期待される．