Basic study for the realization of intensity-modulated carbon-ion beam therapy.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07700
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Osaka University
• Principal Investigator: Minami Kazumasa 大阪大学, 大学院医学系研究科, 准教授 (90634593)
• Co-Investigator(Kenkyū-buntansha): 玉利 慶介 大阪大学, 大学院医学系研究科, 講師 (30718995) ; 高橋 豊 大阪大学, 大学院医学系研究科, 招へい教員 (40353461) ; 金井 達明 大阪大学, 大学院医学系研究科, 招へい教授 (80161149)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 炭素イオン線 / 強度変調粒子線照射

Outline of Final Research Achievements

Carbon-ion beam therapy has achieved good local control for tumors that had previously been treated with poor results. However, the problem of recurrence of refractory tumors still remains, and there is a need to further increase the dose of carbon-ion beam therapy in order to improve treatment outcomes. On the other hand, there are some cases in which the treatment has to be abandoned even though it is known that carbon-ion beam therapy is effective for the tumor because irradiation of the OAR cannot be avoided due to the distorted shape of the tumor, such as tumors in contact with or surrounding organs at risk (hereinafter referred to as “Organs at Risk”). Based on the above two points, this study established a method to protect normal tissues by irradiating carbon ion beams from various directions.

Free Research Field

放射線生物学

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、これまで避けることのできなかった正常組織への照射線量を低減することが可能となった。これにより、炭素イオン線治療が有効な腫瘍と分かりながらも正常組織への影響により治療を断念せざるを得ない症例に対しても十分な炭素イオン線量を照射することが可能となった為、放射線治療の成績が向上するだけでなく適応外であった症例に対する回答が得られた。この点は社会的意義が大きいと考えている。