2023 Fiscal Year Final Research Report
A study on pathophysiological factors inhibiting neurocognitive development in young childhood
| Project/Area Number |
21K07754
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
柴田 敬 岡山大学, 大学病院, 講師 (00769961)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 認知機能発達 / 脳波分析 / 乳幼児 / 高周波振動 / てんかん性脳症 |
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| Outline of Final Research Achievements |
We have already reported that abnormal high-frequency oscillations (HFOs)/fast oscillations (FOs) are observed in scalp electroencephalogram (EEG) in childhood developmental and epileptic encephalopathy (DEE). We intended to disclose the relationship between the generation of HFOs/FOs in EEG and cognitive development through multivariate analysis involving many pediatric patients. It was really unfortunate for us that referred pediatric epilepsy patients drastically decreased during the study period due to the COVID-19 pandemic.
As the secondary project, we analyzed the relationship between non-epileptic (presumably physiological) HFOs/FOs and neurocognitive/neurobehavioral development in 124 children who had autism spectrum disorder and/or attention-deficit/ hyperactivity disorder (ADHD) but not epilepsy. We found that the generation of non-epileptic HFOs/FOs was significantly related with intelligence quotient (IQ)/developmental quotient (DQ) and absence of ADHD.
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| Free Research Field |
小児神経学
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| Academic Significance and Societal Importance of the Research Achievements |
小児頭皮脳波において認める高周波・速波振動 (HFO/FO)と認知機能の関係性について、複数の側面から示すことができた。またこのようなHFO/FOが単なるアーチファクトでないことも証明できた。本来の研究目的の発達性てんかん性脳症におけるHFO/FOと認知発達の関係性の解明に関しては道半ばであるが、小児の認知機能の生理と病態についての重要な手がかりが得られたと考える。
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