Elucidation of the mechanism of diabetes-related liver carcinogenesis through multilayer omics analysis focusing on abnormal glycolipid metabolism

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07896
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Hiroshima University
• Principal Investigator: AIKATA HIROSHI 広島大学, 医系科学研究科(医), 専門研究員 (30403512)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 肝癌 / 糖尿病

Outline of Final Research Achievements

In recent years, the number of patients with non-hepatitis viral liver cancer who are not infected with HBV or HCV has been increasing, but many of these patients have been found to have lifestyle-related diseases such as abnormalities in glucose and lipid metabolism. In this study, we add metabolome, lipidome, and metagenomic information that are closely related to abnormalities in glucose and lipid metabolism, integrate multiple omics information accumulated to date, and identify high-risk groups for non-hepatitis viral hepatocarcinogenesis. The aim was to generate results that would contribute to clinical applications, such as the identification of useful biomarkers.

Free Research Field

肝臓内科

Academic Significance and Societal Importance of the Research Achievements

本邦における糖尿病、脂肪肝など生活習慣病を有している患者は、増加傾向にある。近年、これらの生活習慣病を背景とした脂肪性肝疾患のみならず、肝癌の増加が社会問題となっている。糖尿病患者における肝癌高リスクグループのスクリーニング法は未だ確立されていないが、本研究は、肝発癌機構の解明や非肝炎ウイルス性肝発癌高リスク群のスクリーニングに資することが期待される。