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2023 Fiscal Year Annual Research Report

The establishment of indication for endoscopic resection of ulcerative colitis associated neoplasia according to molecular biological analyses

Research Project

Project/Area Number 21K07924
Research InstitutionUniversity of Toyama

Principal Investigator

渡辺 憲治  富山大学, 学術研究部医学系, 特命教授 (70382041)

Co-Investigator(Kenkyū-buntansha) 味岡 洋一  新潟大学, 医歯学系, 教授 (80222610) [Withdrawn]
池内 浩基  兵庫医科大学, 医学部, 教授 (80319863) [Withdrawn]
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords潰瘍性大腸炎 / 腫瘍 / 分子生物学 / 内視鏡的切除 / 鋸歯状病変
Outline of Annual Research Achievements

潰瘍性大腸炎関連腫瘍の内視鏡的切除例および外科切除例の検体集積、また対照となる散発性大腸腫瘍および鋸歯状病変の内視鏡的切除検体の集積、とpreliminaryな一部の解析を行っていたが、コロナ禍による内視鏡検査や治療施行停止、および研究代表者の施設異動があり、計画に大きな遅延が生じた。こうした病変の病理学的検討を免疫組織学的検討や分子生物学的検討については、分子生物学的検討の手法の課題が一部克服できたが、同様に研究代表者の異動等で大きな遅延が生じた。研究代表者の施設異動後、新たな施設で機材等を購入し、研究の継続を試みたが、前施設に比べ対象症例数がかなり少なく、検討に足る症例数の集積には至らなかった。対象病変の大腸粘膜局所および血中のサイトメガロウイルス感染、またそれらをpromoteする可能性がある生物学的製剤や免疫調節剤など免疫抑制的治療の免疫抑制の程度に関連する指標(生物学的製剤血中濃度や免疫調節剤の代謝物濃度など)、MEFV遺伝子変異例の検討についても、preliminaryな解析で症例数不足の結果であった。
潰瘍性大腸炎関連腫瘍性病変の診療アルゴリズムは、共著者間でコンセンサスを得つつ、欧米のKey Opinin Leaderの意見も参考に改訂し、論文投稿作業中である。

  • Research Products

    (10 results)

All 2024 2023

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Upadacitinib Achieves Clinical and Endoscopic Outcomes in Crohn’s Disease Regardless of Prior Biologic Exposure2024

    • Author(s)
      Peyrin-Biroulet Laurent、Panaccione Remo、Louis Edouard、Atreya Raja、Rubin David T.、Lindsay James O.、Siffledeen Jesse、Lukin Dana J.、Wright John、Watanabe Kenji、Ford Sharanya、Remple Valencia P.、Lacerda Ana P.、Dubcenco Elena、Garrison Andrew、Zhou Qian、Berg Sofie、Anyanwu Samuel I.、Schreiber Stefan
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: Online ahead of print Pages: N/A

    • DOI

      10.1016/j.cgh.2024.02.026

    • Peer Reviewed
  • [Journal Article] Trajectory analyses to identify persistently low responders to COVID-19 vaccination in patients with inflammatory bowel disease: a prospective multicentre controlled study, J-COMBAT2023

    • Author(s)
      Watanabe Kenji、Nojima Masanori、Nakase Hiroshi、et al.
    • Journal Title

      Journal of Gastroenterology

      Volume: 58 Pages: 1015~1029

    • DOI

      10.1007/s00535-023-02029-z

    • Peer Reviewed
  • [Journal Article] Impact of Concomitant Thiopurine on the Efficacy and Safety of Filgotinib in Patients with Ulcerative Colitis: Post?Hoc Analysis of the Phase 2b/3 SELECTION Study2023

    • Author(s)
      Watanabe Kenji、Peyrin-Biroulet Laurent、Danese Silvio、Fujitani Yasushi、Faes Margaux、Oortwijn Alessandra、Lindsay James O、Rogler Gerhard、Hibi Toshifumi
    • Journal Title

      Journal of Crohn's and Colitis

      Volume: Online ahead of print Pages: N/A

    • DOI

      10.1093/ecco-jcc/jjad201

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nationwide multicenter study on adverse events associated with a patency capsule: Additional survey of appropriate use of patency capsule study2023

    • Author(s)
      Omori Teppei、Ohmiya Naoki、Watanabe Kenji、et al.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 39 Pages: 337~345

    • DOI

      10.1111/jgh.16365

    • Peer Reviewed
  • [Journal Article] Geography Influences Susceptibility to SARS-CoV-2 Serological Response in Patients With Inflammatory Bowel Disease: Multinational Analysis From the ICARUS-IBD Consortium2023

    • Author(s)
      Wong Serre-Yu、Wellens Judith、Helmus Drew、Marlow Luke、Brann Stephanie、Martinez Pazos Vicky、Weinberg Alan、Moran Hunter R、McGregor Colleen、Vermeire Severine、Watanabe Kenji、Kamikozuru Koji、et al.
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 29 Pages: 1693~1705

    • DOI

      10.1093/ibd/izad097

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] II.現代の潰瘍性大腸炎サーベイランス内視鏡と今後2023

    • Author(s)
      Watanabe Kenji
    • Journal Title

      Nippon Daicho Komonbyo Gakkai Zasshi

      Volume: 76 Pages: 567~571

    • DOI

      10.3862/jcoloproctology.76.567

    • Peer Reviewed
  • [Presentation] 炎症性腸疾患の診断2024

    • Author(s)
      渡辺憲治
    • Organizer
      第32回日本消化器内視鏡学会北陸セミナー
    • Invited
  • [Presentation] Clinical features and surgical necessity rate of fistulising perianal disease in newly diagnosed patients with Crohn's disease: Interim analysis of inception cohort registry study of patients with Crohn's disease (iCREST-CD)2024

    • Author(s)
      N Takatsu, T Yamamoto, H Nakase, S Shinzaki, K Watanabe, et al.
    • Organizer
      The 19th Congress of European Crohn´s and Colitis Organisation (ECCO)
    • Int'l Joint Research
  • [Presentation] UPADACITINIB IMPROVES CLINICAL OUTCOMES IN PATIENTS WITH MODERATE TO SEVERELY ACTIVE CROHN’S DISEASE IRRESPECTIVE OF PREVIOUS FAILURE TO RESPOND TO BIOLOGICS OR CONVENTIONAL THERAPIES2023

    • Author(s)
      Stefan Schreiber, Allen Lim, Ana Lacerda, Jessica Allegretti, Kenji Watanabe, Dana Lukin, Elena Dubcenco, Sharanya Ford, Jessica Oomen, Qian Zhou, Jianzhong Liu, Edouard Louis
    • Organizer
      Digestive Disease Week 2023
    • Int'l Joint Research
  • [Book] 新訂NBI内視鏡アトラス2023

    • Author(s)
      渡辺憲治、西下正和/山上博一
    • Total Pages
      316
    • Publisher
      南江堂

URL: 

Published: 2024-12-25  

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