The establishment of indication for endoscopic resection of ulcerative colitis associated neoplasia according to molecular biological analyses

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07924
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: University of Toyama (2023); Hyogo Medical University (2021-2022)
• Principal Investigator: Watanabe Kenji 富山大学, 学術研究部医学系, 特命教授 (70382041)
• Co-Investigator(Kenkyū-buntansha): 味岡 洋一 新潟大学, 医歯学系, 教授 (80222610) ; 池内 浩基 兵庫医科大学, 医学部, 教授 (80319863)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 潰瘍性大腸炎 / 腫瘍 / 分子生物学 / 内視鏡的切除 / 鋸歯状病変

Outline of Final Research Achievements

The accumulation of specimens of endoscopically and surgically resected cases of ulcerative colitis-associated neoplasms (UCAN) and the collection and preliminarily analysis of control sporadic colorectal neoplasms and serrated lesions were being conducted, but there were significant delays in planning due to the suspension of endoscopy due to the COVID-19 pandemic and the transfer of principal investigators' institution. There were major delays for the molecular biological study due to the transfer of the principal investigator. After the Principal Investigator's transfer to a new institution, we prepared equipment and attempted to continue the study at the new institution, but the number of cases was considerably smaller than at the previous institution and we were unable to accumulate a sufficient number of cases for the study. A treatment algorithm for UCAN is in the process of being submitted for publication.

Free Research Field

炎症性腸疾患

Academic Significance and Societal Importance of the Research Achievements

欧米から発表されている文献は、潰瘍性大腸炎関連腫瘍に対する内視鏡所見と病理学的所見の対比を行っていないが、我々のアルゴリズムは、こうした検討をベースに作成した意義を有する。潰瘍性大腸炎サーベイランス内視鏡の現況の課題を浮き彫りにし、臨床現場で実施可能な知見を提供する本検討であったが、研究代表者の施設移動やCOVID-19パンデミックによる内視鏡検査の大きな制限が影響し、十分な症例集積ができなかった。
内視鏡機器は進歩を重ねており、最新の内視鏡機器に対応した研究を再度、構築して参りたい。