Development of biomarkers for early diagnosis of chronic pancreatitis

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07930
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Tohoku University
• Principal Investigator: Kikuta Kazuhiro 東北大学, 医学系研究科, 非常勤講師 (80420024)
• Co-Investigator(Kenkyū-buntansha): 濱田 晋 東北大学, 大学病院, 助教 (20451560) ; 正宗 淳 東北大学, 医学系研究科, 教授 (90312579)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 慢性膵炎

Outline of Final Research Achievements

Most cases of chronic pancreatitis are irreversible, so the establishment of early diagnostic methods is an important issue. We conducted research to explore pathophysiology, clinical picture, and biomarkers for early diagnosis of chronic pancreatitis. We collected pancreatic fluid when pancreatic fluid drainage was performed due to medical necessity. Patients with early chronic pancreatitis were enrolled and prospectively observed. We examined the relationship between pancreatic exocrine function and pancreatic endocrine function and clinical presentation, the relationship between alcohol consumption and clinical presentation, muscle mass, pain management in elderly patients, and nutritional intake status in patients with chronic pancreatitis.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

慢性膵炎の多くは非可逆性であり、その早期診断は重要な課題と考えられている。従来の慢性膵炎の診断基準は、進行した慢性膵炎の診断に有用であるが、慢性膵炎の新しい定義であるmechanistic definitionに基づいて、様々な視点から様々な病期の慢性膵炎の病態や臨床像、バイオマーカーを明らかにすることにより、今後、慢性膵炎の早期診断法の確立につながることが期待される。