Identification of Metabolomic Profile in Early Mortality Patients with Heart Failure

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Shinshu University
• Principal Investigator: Motoki Hirohiko 信州大学, 学術研究院医学系, 准教授 (50532058)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 心不全 / 終末期 / メタボロミクス

Outline of Final Research Achievements

Identifying metabolomic profile in elderly patients with heart failure, especially in early mortality cases, would be useful biomarkers for indicating palliative/end-of-life care. We conducted a prospective observational study of patents with HF. Patients were candidates who met any one of following criteria; 1) cardiovascular death (CVD) within 3 months, 2) CVD within 3-6 months, 3) survival more than 2 years (Control). Randomly selected 10 patients in group 1-3 were enrolled. Metabolomic analysis was performed in total 28 patients. Partial least squares-discriminant analysis showed higher relative area of Urea and Symmetric dimethylarginine were associated with mortality, and lower relative area of Carnitine were associate with mortality within 3 months. Metabolome analysis could clarify clinical features of early mortality cases in elderly patients with HF. Carnitine, Urea, and SDMA would be useful biomarkers for monitoring the course to death.

Free Research Field

心不全

Academic Significance and Societal Importance of the Research Achievements

心不全患者の緩和ケア、終末期ケアのニーズが高まっているが、死亡時期の予測が難しいためこれらの普及には困難がみられていた。本研究結果により患者の病みの軌跡がより明確となれば、患者・家族・医療者が同じ認識のもとにケアに当たることが可能となると考えられる。