Gut kidney axis in diabetic kidney disease

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Kanazawa University
• Principal Investigator: Yasunori Iwata 金沢大学, 医学系, 教授 (90432137)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 糖尿病関連腎臓病 / 腸管環境

Outline of Final Research Achievements

In recent years, it has become clear that the gut microbiota and its metabolites are involved in maintaining homeostasis in the body, and that dysbiosis of gut microbiota is involved in the onset and progression of various diseases. It has also been shown that the intestinal environment is deeply involved in the pathophysiology of kidney disease. We have clarified that intestinal bacterial cells are involved in the progression mechanism of diabetic kidney disease. In a mouse model of diabetic kidney disease, we showed that intestinal bacteria are translocated into the body due to leaky gut, resulting in chronic inflammation. This suggests that the intestinal epithelium may be a new therapeutic target for diabetic kidney disease.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

本邦の慢性腎臓病患者は、約１３３０万人と推定されており、新たな国民病とも考えられている。治療手段はいまだ限られており、新規の病態解明や治療薬の開発が求められている。本研究課題で得られた知見は、糖尿病関連腎臓病の新たな病態と治療標的の可能性を示しており、将来的な臨床応用の基盤となる結果であると考えられる。