2023 Fiscal Year Final Research Report
Development of vaccine against chronic kidney disease
Project/Area Number |
21K08263
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53040:Nephrology-related
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Keywords | 慢性腎臓病 / ワクチン |
Outline of Final Research Achievements |
The aim of this study was to develop a therapeutic vaccine targeting connective tissue growth factor (CTGF) to prevent and treat chronic kidney disease (CKD) with high unmet medical needs, thereby providing a novel treatment strategy for CKD. Short peptide sequences suitable for vaccine antigens were identified from the amino acid sequence of CTGF, and a vaccine antigen was created. After evaluating the optimal immunization protocol, the therapeutic effect of the anti-CTGF vaccine on CKD was comprehensively examined using adenine-induced CKD model mice and renal interstitial fibrosis model mice (unilateral ureteral obstruction). These experiments revealed the inhibitory effect of the anti-CTGF vaccine on renal fibrosis.
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Free Research Field |
腎臓内科学
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、CTGFの作用を抑制することで、マウスの腎線維化の進行を遅らせることが、2つの疾患モデルにて明確に示され、今後の創薬の進展につながる可能性がある。また、慢性疾患に対する治療モダリティとして、「ワクチン」を利用したことは、少ない投薬回数で長期間にわたる治療効果の持続が期待されるため、服薬アドヒアランスや医療費抑制の観点からも望ましい。このような新規の取り組みは、これまで治療選択肢の少なかった慢性腎臓病領域において、新たに一石を投じるものと期待される。
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