Pathology and clinical profile of atopic dermatitis associated with CARD11 mutation

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08293
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: University of Tsukuba
• Principal Investigator: Inaba Masako 筑波大学, 附属病院, 病院助教 (60881521)
• Co-Investigator(Kenkyū-buntansha): 原 博満 鹿児島大学, 医歯学域医学系, 教授 (20392079) ; 野口 恵美子 筑波大学, 医学医療系, 教授 (40344882)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: CARD11 / アトピー性皮膚炎 / 抗原特異的T細胞

Outline of Final Research Achievements

We analysed the prevalence and variant patterns of CARD11 gene variants in a population of Japanese patients with atopic dermatitis.
Blood samples from patients with atopic dermatitis and healthy controls were also collected to identify T cells that specifically act on mites, the major antigen of atopic dermatitis. In addition, the frequency and phenotype of mite-specific regulatory T cells (Tregs) and mite-specific effector T cells (Teffs) were examined in patients with atopic dermatitis and healthy controls to determine the balance between Tregs and Teffs acting on a single antigen.

Free Research Field

免疫、アレルギー

Academic Significance and Societal Importance of the Research Achievements

アトピー性皮膚炎の発症が単一抗原に対して特異的に働くTregとTeffのバランスで規定されることがわかった。アトピー性皮膚炎の病態研究において抗原特異的T細胞に着目した研究はこれまでになく、本研究結果から、皮膚において抗原特異的にTregを誘導する様な免疫療法を開発することができれば、健常者に近いTreg優位のT細胞免疫バランスを作り出すことができ、アトピー性皮膚炎の根治的治療となり得ると期待される。