Epithelial–immune microenvironment (EIME) in acne

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08303
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Kagawa University
• Principal Investigator: Dainichi Teruki 香川大学, 医学部, 教授 (20423543)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ざ瘡

Outline of Final Research Achievements

This study addresses the epithelial-immune cell circuit in the pathogenesis of acne, leading to the creation of novel therapies and prevention. To evaluate the pathology of the follicular sebaceous gland system in experimental animals, first, Rhino mice were introduced from The Jackson Laboratory, USA, and transcriptome analysis was performed during the course of chemical peeling. Second, an acne animal model system was established using B6 mice by continuous topical application of fatty acids, and the suppression of the development of the disease by candidate low-molecular-weight compounds was evaluated.

Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

ざ瘡は患者数でも経済規模でも人類最大の皮膚疾患でありながら、治療面において、1982年に発見されたイソトレチノインによるざ瘡の抑制作用に匹敵する進歩は40年以上みられない。とくに本邦ではざ瘡の基礎研究にかかわる研究者はごく限られる。本研究は、ざ瘡という疾患において、研究面で今後、アトピー性皮膚炎や乾癬の領域に匹敵する発展をリードしうる、先進的な取り組みとして位置づけることができる。