2023 Fiscal Year Final Research Report
The role of extracellular matrix in immune escape and progression in the skin cancer microenvironment
| Project/Area Number |
21K08321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | University of Fukui |
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Principal Investigator |
Oyama Noritaka 福井大学, 学術研究院医学系部門, 准教授 (30332927)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 細胞外基質 / 皮膚癌微小環境 / 黒色腫 / 有棘細胞癌 / ECM1 |
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| Outline of Final Research Achievements |
ECM1-deficient mice were transplanted with skin-derived cancer cell lines (spinous cell carcinoma and melanoma) to analyze the mechanisms of their local maintenance and progression. Conventional methods were used to generate ECM1 gene-deficient mice, but all of them died during the embryonic period. This result suggests that ECM1 is not only a disease susceptibility gene but also a developmentally important molecule. We next created an organ-specific ECM1-deficient state by a conditioned KO method, and further analyzed cultured dermal fibroblasts treated by the siRNA method targeting ECM1 gene alone.
The KO human model for ECM1 gene, mucocutaneous hyalinosis, is a genetic disease without fetal lethality or prognostic value for life. The present results indicate a differential, unidentified ECM1 function between human and mice.
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| Free Research Field |
皮膚腫瘍免疫
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果が癌間質分子を標的とする創薬に結び付いた際には、癌自体を標的とする既存の抗癌剤との併用も可能な作用機序である点からも、相乗効果や耐性の獲得を一層回避できる治療戦略を構築できる可能性が高く、学術的にも社会的にも貢献度の高い研究テーマであると考えている．
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