Establishment of psoriasis biomarkers using keratinocytes

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08334
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Toho University
• Principal Investigator: Ishiko Akira 東邦大学, 医学部, 教授 (10202988)
• Co-Investigator(Kenkyū-buntansha): 橋本 由起 東邦大学, 医学部, 講師 (60439982)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 乾癬 / バイオマーカー

Outline of Final Research Achievements

We quantified S100A8/A9 in corneocytes taken by tape stripping method from many psoriasis patients and investigated its usefulness as a disease biomarker. The corneocyte S100A8/A9 showed a weak correlation with PASI score, which was parallel to the movement of PASI before and after treatment. The temporal S100A8/A9 quantification also paralleled disease activity. The correlation between S100A8/A9 and the mPASI score at the same site of measurement was stronger than that of the whole-body PASI score, indicating that S100A8/A9 is an objective biomarker of disease status in the evaluation of local therapy for psoriasis, regardless of the type of treatment.

Free Research Field

医学　皮膚科学

Academic Significance and Societal Importance of the Research Achievements

乾癬の病勢を評価する方法は医師が患者の皮膚症状を診察し、主観的に算出するPASIスコアが汎用されている。我々が用いたテープストリッピング法を用いて角質細胞を採取し、S100A8/A9を定量する方法は、乾癬患者の病態、病勢を反映する非侵襲的で客観的な病勢バイオマーカーとして極めて有用であることが示され、乾癬患者の治療アウトカムの客観的な評価が可能となり、薬剤開発の臨床治験への応用などが期待できる。