Viral Discovery and Clinical Application for B-Cell Tumors

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08402
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Saitama Medical University
• Principal Investigator: Yasuhito TERUI 埼玉医科大学, 医学部, 教授 (10285786)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: B細胞腫瘍 / 悪性リンパ腫 / 多発性骨髄腫 / ウイルス / Virome解析

Outline of Final Research Achievements

To clarify the significance of viral infection in the pathogenesis and disease progression of B-cell tumors, malignant lymphoma and multiple myeloma, nine patients with malignant lymphoma and 20 patients with multiple myeloma were enrolled based on a research protocol approved by an ethics committee. Virome coverage analysis using high-quality RNA extracted from tumor cells of 6 patients with malignant lymphoma and 16 patients with multiple myeloma identified 15 types of bacteriophages and 16 types of viruses.
Virome analysis by next-generation sequencing is useful as a screening test to identify viruses that may be involved in the pathogenesis or progression of B-cell tumors, but further investigation of the involvement of the identified viral groups in the pathogenesis or progression of disease is needed.

Free Research Field

造血器腫瘍学

Academic Significance and Societal Importance of the Research Achievements

B細胞性腫瘍の発症や増悪進行に関与の可能性のあるウイルスの同定法として次世帯シークエンサーによるVirome解析はスクリーニング検査として有用であるが、同定されたウイルス群の発症や病勢増悪への関与をさらに追求する必要がある。
B細胞性腫瘍の発症や増悪進行に関連したウイルスの関与メカニズムを明らかにすることは疾患治療、予防に繋げることが可能となる。