2023 Fiscal Year Final Research Report
The analysis of T follicular helper and regulatory cells of patients with atopic asthma comorbid with allergic rhinitis by treated with HDM-SLIT
| Project/Area Number |
21K08441
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
亀倉 隆太 札幌医科大学, 医学部, 講師 (70404697)
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | 濾胞ヘルパーT細胞 / 濾胞制御性T細胞 / 制御性T細胞 / 制御性B細胞 / ダニ特異的免疫グリブリン / アレルギー性気道疾患 / ダニ舌下免疫療法 |
|---|
| Outline of Final Research Achievements |
We performed house dust mite sublingual immunotherapy (HDM-SLIT) for 20 patients with atopic asthma comorbid with allergic rhinitis (AA+AR). Based on the symptom score and medication score in patients with AA, the patients were divided into responders and non-responders. The percentage of cTfh2 cells significantly decreased within the first year. Der-p/f sIgEs decreased after a transient elevation at 3 months in both groups. Notably, the percentage of cTfh2 cells and the ratio of cTfh2/cBreg cells and Der-p/f sIgEs greatly decreased in responders from 6 months to 12 months. The percentages of cTfr showed significant negative correlations with the percentage of cTfh2 cells.
We performed multi-plelogistic regression analysis based on these results, the ratios of cTfh2/cTfr cells and cTfh2/cBreg cells at the start of therapy were statistically effective biomarkers for predicting the response to HDM-SLIT in patients with AA+AR.
|
| Free Research Field |
アレルギー性気道炎症
|
| Academic Significance and Societal Importance of the Research Achievements |
今回の研究で、上下気道におけるダニアレルギー疾患の日本人における有効性が再確認され、治療開始にあたり有効性を予見する免疫学的指標が示された。
|
