Mechanisms of skeletal muscle remodeling processes activated by exercise and attenuated by aging

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08530
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: The University of Tokushima (2023); Kobe University (2021-2022)
• Principal Investigator: NOMURA Kazuhiro 徳島大学, 大学院医歯薬学研究部(医学域), 講師 (70450236)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 骨格筋 / 肥満 / エネルギー代謝 / アドレナリンシグナル / サルコペニア

Outline of Final Research Achievements

In skeletal muscle of aging mice, the accumulation of inflammatory cells is known to be delayed during the repair and remodeling process of damaged muscle, but this delayed accumulation of inflammatory cells is ameliorated in mice that that undergo training exercise. In "exercise-resistant" skeletal muscle-specific β2-adrenergic receptor-deficient mice, the accumulation of inflammatory cells during the repair and remodeling process of damaged muscle was delayed, and no improvement was observed with exercise. These results led to the identification of several candidate factors involved in signals that are attenuated by aging and activated by exercise.

Free Research Field

代謝学

Academic Significance and Societal Importance of the Research Achievements

本研究では運動によって活性化され、加齢によって減弱する骨格筋リモデリングプロセスの起点となるシグナルに関わる候補因子の同定に至った。このような因子の解析をさらにすすめることで、サルコペニアの新規な治療法・治療薬の開発に発展させることが期待できる。