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2023 Fiscal Year Final Research Report

Elucidation of the pathogenesis of early diabetic neuropathy focusing on the intestinal microflora and establishment of new treatment methods

Research Project

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Project/Area Number 21K08546
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionHirosaki University

Principal Investigator

Kudoh Kazuhiro  弘前大学, 医学研究科, 客員研究員 (50772026)

Project Period (FY) 2021-04-01 – 2024-03-31
Keywords糖尿病性神経障害 / 小径神経障害 / 腸内細菌 / 岩木健康増進プロジェクト
Outline of Final Research Achievements

We could patriciate the Iwaki Health Promotion Project held in 2022. Because it was in the midst of a COVID-19 infection, we could examine the pain threshold test (PINT) only on approximately 800 individuals. The 2022 data is currently being analyzed. In addition, data from the Iwaki Health Promotion Project in 2017 was used to examine the relationship between PINT index and the body's bacterial flora. As a result, no association was found between oral bacterial flora and pain threshold. In contrast, there was a significant correlation between PINT index and the intestinal microflora. In particular, a significant correlation was found between a decrease in Bacteroides genus and a worsening of the PINT index.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

痛覚閾値検査(PINT)は小径神経障害の程度を反映している。小径神経障害は糖尿病性神経障害などで発症するが、その病態、発症因子は糖代謝以外ははっきり解明されていなかった。本研究により初めて糖代謝以外の因子が小径神経障害に関連していることが解明された。腸内細菌、つまりバクテロイデス属の減少と相関がみられたことから、生活習慣、特に食生活の改善により小径神経障害の改善がもたらされる可能性がある。特に、糖尿病性神経障害に関連している小径神経障害に対しては、血糖管理に加えて生活習慣を改善する大きな動機付けになると考えられた。

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Published: 2025-01-30  

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