Mechanistic elucidation of thermogenesis by brown/beige adipocytes and application for the treatment of obesity and diabetes

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08582
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Iwate Medical University
• Principal Investigator: Hasegawa Yutaka 岩手医科大学, 医学部, 特任准教授 (90451559)
• Co-Investigator(Kenkyū-buntansha): 武部 典子 岩手医科大学, 医学部, 講師 (30398474) ; 石垣 泰 岩手医科大学, 医学部, 教授 (50375002)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 肥満症 / メタボリックシンドローム / 脂肪細胞 / 脱共役タンパク質１

Outline of Final Research Achievements

We performed the screening to identify compounds that activate thermogenesis in adipocytes and identified four candidate compounds. We elucidated that one compound can serve as a potential therapeutic drug for the treatment of obesity and its related metabolic disorders. A further comprehensive analysis revealed that thermogenic actions by this identified compound were mediated by the PKA-p38 MAPK pathway.

Free Research Field

肥満・メタボリックシンドローム

Academic Significance and Societal Importance of the Research Achievements

新規肥満の候補薬となる化合物を同定できた。同定した化合物の安全性と効果、作用機序を解明した。将来的な新規肥満治療の応用につながる可能性がある。