2023 Fiscal Year Final Research Report
Development of the strategy to improve sarcopenia in streptozotocin-treated mice by modulation of amino acids in the white muscle.
| Project/Area Number |
21K08583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
久保 亜紀子 神戸大学, 医学研究科, 特命講師 (50455573)
木内 謙一郎 慶應義塾大学, 医学部(信濃町), 講師 (50528578)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | サルコペニア / BCAA / ミトコンドリア / エピゲノム / ヒストンアセチル化 |
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| Outline of Final Research Achievements |
Sarcopenia predicts and is associated with the onset of cardiovascular disease, the importance of sarcopenia prevention is attracting attention in a wide range of medical and nursing care fields. Since the mechanism has not been fully elucidated at least from a metabolic perspective, the present study analyzed the skeletal muscle of type 1 diabetes model mice with streptozotocine using imaging mass spectrometry. In addition, in the skeletal muscle of mice subjected to intermittent fasting, we analyzed the epigenome of the fatty acid oxidation gene cluster. As a result, we found that BCAA accumulation in the skeletal muscle may be involved in sarcopenia that is associated with type 1 diabetes. Histone acetylation in skeletal muscle mitochondria-related genes may be involved in improving endurance associated with intermittent fasting
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| Free Research Field |
Endocrinology
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| Academic Significance and Societal Importance of the Research Achievements |
1型糖尿病に伴うサルコペニアの改善に, 骨格筋BCAA代謝変容の修正が有用である可能性が示唆された.
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