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2023 Fiscal Year Final Research Report

Effects of cold static strage on myocardial function of hearts donated after circulatory death

Research Project

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Project/Area Number 21K08825
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55030:Cardiovascular surgery-related
Research InstitutionKyushu University

Principal Investigator

Shiose Akira  九州大学, 医学研究院, 教授 (30363336)

Co-Investigator(Kenkyū-buntansha) 内山 光  九州大学, 大学病院, 医員 (30896022)
松田 健作  九州大学, 大学病院, 医員 (40792924)
牛島 智基  九州大学, 大学病院, 助教 (70529875)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords心臓移植 / DCD / 浸漬保存
Outline of Final Research Achievements

We used a porcine model to study cardioprotection in controlled donation after Ciruclatory Death (cDCD). After hypoxic cardiac arrest, the heart was reanimated with a veno-arterial extracorporeal membrane oxygenator (V-A ECMO) and then the heart was explanted. After cold static strage, the heart was reanimated by reperfusion of oxygenated blood with ECMO. Cold static storage might be possible in cDCD hearts as in donation after brain death. In addition, the acceptable cold ischemic time for DCD hearts exposed to 30 minutes of warm ischemia was about 30 minutes in a procedure that did not use any other specific cardioprotective methods. For clinical application, further investigation of comparisons with other cardioprotective solutions, effects of drug addition, etc., and comparison of cardiac function indices after cardiac transplantation are needed.

Free Research Field

循環器外科学分野

Academic Significance and Societal Importance of the Research Achievements

本邦は諸外国と比較しても心臓移植待機期間が長く、待機中の死亡や合併症発生は大きな問題といえる。ドナー不足解消の一つの方法としてcDCD心臓移植があり、海外での報告が増えてきているが、本邦における導入のためには解決すべき問題が多数存在する。とりわけ、保存運搬時の温虚血・冷虚血の与える影響においては不明な点が多く、適切な保存法に関しての議論は医療経済的な側面も含め解決を得ていない。本研究では、浸漬保存による可能性の一端が示され、次なる研究の道標になる可能性がある。

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Published: 2025-01-30  

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