2023 Fiscal Year Final Research Report
comparison between LV venting and IMPELLA under V-A ECMO
| Project/Area Number |
21K08869
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55030:Cardiovascular surgery-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
仁田 翔大 九州大学, 大学病院, 医員 (70769801)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | central ECMO / Impella / LV unloading |
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| Outline of Final Research Achievements |
The purpose of this study is to validate the efficacy of Impella as an LV unloading method for severe acute circulatory failure.We aim to compare the efficacy of two types of LV unloading in a porcine acute myocardial infarction + V-A ECMO model.The purpose of this study is to compare 3 groups: (1) ECMO alone, (2) ECMO + surgical LV venting, and (3) ECMO + Impella, and to examine hemodynamics during circulatory assistance, cardiac function in the acute phase after withdrawal of circulatory assistance, and cardiac function and myocardial remodeling in the chronic phase after withdrawal of circulatory assistance.
A trend toward preservation of cardiac function was observed in group (2). As for group (3), we were not able to obtain data that could be compared with the other two groups.
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| Free Research Field |
心不全
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| Academic Significance and Societal Importance of the Research Achievements |
IMPELLAが外科的左室ベントと同等のLV unloading効果を発揮することの証明には至らなかったが、そのための実験のモデルの確立に成功した。今後同モデルを用いて、デバイス関連の実験データの蓄積が期待される。
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