The effect of Anesthetics via microRNA

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08934
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Nippon Medical School
• Principal Investigator: Ishikawa Masashi 日本医科大学, 医学部, 准教授 (30714745)
• Co-Investigator(Kenkyū-buntansha): 岩崎 雅江 日本医科大学, 医学部, 講師 (20744428) ; 坂本 篤裕 日本医科大学, 大学院医学研究科, 大学院教授 (30196084) ; 間瀬 大司 日本医科大学, 医学部, 講師 (60614831)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: Anesthetics

Outline of Final Research Achievements

[The effect of anesthetics for septic acute kidney injury (AKI)] Dexmedetomidine exacerbated renal dysfunction in septic rats, while midazolam had a renal protective effect via NFκB pathway. It was suggested that midazolam may have a renal protective effect via NFκB pathway in septic AKI.
[The pro- or anti-cancer effect of sympathomimetic drugs] It was shown that norepinephrine-induced changes in HRAS, VEGFA, and TGFBR2 expression could be canceled by administration of β-blocker. Intraoperative administration of β-blocker may improve the postoperative prognosis of lung cancer through inhibition of the NAD reaction.

Free Research Field

Anesthesiology

Academic Significance and Societal Importance of the Research Achievements

全身麻酔の作用は不明な点が多く、我々は麻酔薬は敗血症における腎機能障害や癌細胞に影響するのではないかと考え検討した。敗血症においてはデクスメデトミジンの腎障害増悪、ミダゾラムの腎保護作用とそれぞれの機序を、肺癌細胞においてはβ遮断薬による腫瘍細胞抑制効果とその機序を示すことができた。本研究の結果は、周術期管理の安全だけではなく長期予後の改善につながり、未だ詳細が不明な麻酔薬の機序を明らかにする一助になる。