2023 Fiscal Year Final Research Report
Development of a new rapid diagnostic method and early phase pathology analysis in coagulation fibrinolysis disorders
| Project/Area Number |
21K09089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | Tenri University (2023)
Tenri Health Care University (2021-2022) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野上 恵嗣 奈良県立医科大学, 医学部, 教授 (50326328)
下村 大樹 天理医療大学, 医療学部, 特別研究員 (70723302)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 凝固波形解析 / 出血症状 / 凝固線溶波形解析 |
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| Outline of Final Research Achievements |
Our research was active in coagulation waveform analysis (CWA), especially CWA using APTT (APTT-CWA). In the future, standardization is an issue to be resolved. We used AI to differentiate coagulation disorders showing APTT prolongation. The results were better than classification using only a few parameters.
We plan to establish a DOACS monitoring method as an application of coagulation waveform analysis. The significance of the coagulation fibrinolysis waveform (CFWA) is often unknown. We investigated the importance of the waveforms in the FDP fractionation using Immunoblot, focusing on the fibrinolytic phase. The results showed different patterns of fibrinolysis in healthy subjects and patients with decreased coagulation factors.
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| Free Research Field |
血栓止血学
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| Academic Significance and Societal Importance of the Research Achievements |
凝固波形解析は検査室で測定できる凝固モニタリング法である。出血症状を評価する凝固機能評価法として有用であるため、今後、AIを用いて、出血症状の原因を鑑別できるツールとして汎用性の向上を目指す。また、凝固線溶波形解析は応用した方法で、凝固から起こるフィブリン溶解過程を観察できる。これらの波形の示す意義を解明した。
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