Elucidation of the Rupture Mechanism by Highly Pathogenic Caries-Causing Bacteria as a Risk Factor in Cerebral Artery Aneurysm Rupture

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: umemura kazuo 浜松医科大学, 医学部, 教授 (40232912)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 脳動脈瘤 / マウス

Outline of Final Research Achievements

Inflammation is considered a cause of cerebral aneurysm rupture. Atherosclerotic lesions induced by hyperlipidemia were examined. By using mice deficient in LDL receptors and Apobec1, hyperlipidemia was induced, and cerebral aneurysms were experimentally induced to observe changes in the development and rupture of cerebral aneurysms. Brain tissues were extracted and evaluated three weeks after the experiment began. In the control group, 58.8% of the animals developed subarachnoid hemorrhage. On the other hand, only 3.5% of the animals with high LDL hyperlipidemia developed subarachnoid hemorrhage. The vascular structure was rich in collagen fibers, suggesting a protective effect against cerebral aneurysm rupture."

Free Research Field

循環薬理学

Academic Significance and Societal Importance of the Research Achievements

脳動脈瘤の破裂は生命を危険にさらし、命を取り留めたとしても介護が必要な状態を招く可能性が高い。破裂のメカニズムを解明することで、予防できる可能性が高まる。今回の研究では、マウスを使用し、そのメカニズムを解明することを目的として行われた。この結果から示されたことは、血管壁の線維化は破裂に対して、保護的に働くことを示唆された。