Real-time precision functional network mapping of the human brain for neurosurgical applications

2022 Fiscal Year Research-status Report

• Project/Area Number: 21K09149
• Research Institution: Nagoya University
• Principal Investigator: Bagarinao E. 名古屋大学, 医学系研究科(保健), 准教授 (00443218)
• Co-Investigator(Kenkyū-buntansha): 礒田 治夫 名古屋大学, 脳とこころの研究センター(保健), 教授 (40223060) ; 前澤 聡 名古屋大学, 医学系研究科, 准教授 (90566960)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: precision mapping / functional connectivity / real-time fMRI / essential tremor / resting state fMRI / human connectome

Outline of Annual Research Achievements

For the FY2022, we have scanned 10 more healthy volunteers, completing the MRI scans of all 20 healthy controls. All participants underwent two imaging sessions, about one month apart. Acquired MRI data includes structural T1 MRI data, an hour of resting state functional MRI data, and diffusion-weighted MRI data. Additionally, we have also acquired the MRI data from patients with essential tremor. Preliminary analysis of the acquired datasets from healthy controls have shown that the reliability of the whole-brain FCOR map exhibited an initial rapid increase as more volumes are incorporated into the analysis. With more volumes added, the reliability measure later plateaus suggesting an upper limit to the reliability as well as an optimal number of volumes to achieve this limit. We have also started the analysis of the data from patients with essential tremor. This will be completed in FY2023.

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

The implementation of the project in the second year was progressing smoothly as planned. With all the data acquired, we have started the full analysis, which we plan to complete in FY2023.

Strategy for Future Research Activity

For the FY2023, we will complete the full analysis of the acquired MRI data. The results of the analysis will be presented in upcoming domestic and international conferences and will be organized into a manuscript to be submitted for possible publication in international journals.

Causes of Carryover

The remaining amount will be used for the promotion of research findings, including presentations in domestic conferences and payment for publications.

Research Products

• [Journal Article] Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor (2023)
  • Author(s): Kato Sachiko、Maesawa Satoshi、Bagarinao Epifanio、Nakatsubo Daisuke、Tsugawa Takahiko、Mizuno Satomi、Kawabata Kazuya、Tsuboi Takashi、Suzuki Masashi、Shibata Masashi、Takai Sou、Ishizaki Tomotaka、Torii Jun、Mutoh Manabu、Saito Ryuta、Wakabayashi Toshihiko、Katsuno Masahisa、Ozaki Norio、Watanabe Hirohisa、Sobue Gen
  • Journal Title: Journal of Neurosurgery Volume: 138 Pages: 306～317
  • DOI: 10.3171/2022.5.JNS22411
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Functional connector hubs in the cerebellum (2022)
  • Author(s): Kawabata Kazuya、Bagarinao Epifanio、Watanabe Hirohisa、Maesawa Satoshi、Mori Daisuke、Hara Kazuhiro、Ohdake Reiko、Masuda Michihito、Ogura Aya、Kato Toshiyasu、Koyama Shuji、Katsuno Masahisa、Wakabayashi Toshihiko、Kuzuya Masafumi、Hoshiyama Minoru、Isoda Haruo、Naganawa Shinji、Ozaki Norio、Sobue Gen
  • Journal Title: NeuroImage Volume: 257 Pages: 119263～119263
  • DOI: 10.1016/j.neuroimage.2022.119263
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Involvement of cerebellar and subcortical connector hubs in schizophrenia (2022)
  • Author(s): Yamamoto Maeri、Bagarinao Epifanio、Shimamoto Masanori、Iidaka Tetsuya、Ozaki Norio
  • Journal Title: NeuroImage: Clinical Volume: 35 Pages: 103140～103140
  • DOI: 10.1016/j.nicl.2022.103140
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reproducibility of functional connectivity metrics estimated from resting-state functional MRI with differences in days, coils, and global signal regression (2022)
  • Author(s): Kato Sanae、Bagarinao Epifanio、Isoda Haruo、Koyama Shuji、Watanabe Hirohisa、Maesawa Satoshi、Hara Kazuhiro、Katsuno Masahisa、Naganawa Shinji、Ozaki Norio、Sobue Gen
  • Journal Title: Radiological Physics and Technology Volume: 15 Pages: 298～310
  • DOI: 10.1007/s12194-022-00670-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson’s disease (2022)
  • Author(s): Bagarinao Epifanio、Kawabata Kazuya、Watanabe Hirohisa、Hara Kazuhiro、Ohdake Reiko、Ogura Aya、Masuda Michihito、Kato Toshiyasu、Maesawa Satoshi、Katsuno Masahisa、Sobue Gen
  • Journal Title: Brain Communications Volume: 4 Pages: fcac214
  • DOI: 10.1093/braincomms/fcac214
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Impairments of connector hubs in brain disorders (2023)
  • Author(s): Epifanio Bagarinao
  • Organizer: 25th Congress of Japan Human Brain Mapping Society
  • Invited
• [Presentation] Characteristics of the aging brain of healthy older adults: A longitudinal study (2022)
  • Author(s): Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Kazuya Kawabata, Kazuhiro Hara, Reiko Ohdake, Aya Ogura, Daisuke Mori, Shuji Koyama, Masahisa Katsuno, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue
  • Organizer: 45th Annual Meeting of the Japan Neuroscience Society