2023 Fiscal Year Annual Research Report
Real-time precision functional network mapping of the human brain for neurosurgical applications
| Project/Area Number |
21K09149
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| Research Institution | Nagoya University |
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Principal Investigator |
Bagarinao E. 名古屋大学, 医学系研究科(保健), 准教授 (00443218)
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| Co-Investigator(Kenkyū-buntansha) |
礒田 治夫 聖隷クリストファー大学, リハビリテーション科学研究科, 臨床教授 (40223060)
前澤 聡 名古屋大学, 医学部附属病院, 助教 (90566960)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | precision mapping / functional connectivity / real-time fMRI / essential tremor / resting state fMRI / human connectome |
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| Outline of Annual Research Achievements |
For FY2023, we have completed the analysis of the acquired MRI data for both healthy volunteers and patients with essential tremor. As reported last year, the reliability of the generated FCOR maps, as measured by the similarity metric, generally exhibited an initial exponential increase with the number of included volumes and then plateaued, suggesting an upper limit and an optimal number of volumes to achieve this limit. For the FCOR analysis of patients with essential tremor, we have identified cerebellar and thalamic connector hubs that exhibited more extensive connections with the sensorimotor and visual networks in patients compared to controls. These altered connections were also negatively correlated with cognitive, tremor, and motor function improvement scores.
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[Journal Article] Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor2024
Author(s)
Epifanio Bagarinao, Satoshi Maesawa, Sachiko Kato, Manabu Mutoh, Yoshiki Ito, Tomotaka Ishizaki, Takafumi Tanei, Takashi Tsuboi, Masashi Suzuki, Hirohisa Watanabe, Minoru Hoshiyama, Haruo Isoda, Masahisa Katsuno, Gen Sobue, Ryuta Saito
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Journal Title
Parkinsonism & Related Disorders
Volume: 121
Pages: 106034～106034
DOI
Peer Reviewed
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