Elucidation of the mechanism of malignant trait acquisition molecules in ependymoma induced by EphB4

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Kanazawa University
• Principal Investigator: Shukur Hemrasabit 金沢大学, 医学系, 協力研究員 (10432113)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ependymoma / EphB4 / ephrin B2

Outline of Final Research Achievements

The ephrin signaling system (erythropoietin-producing hepatocellular receptor (Eph)/ephrin) is an intercellular signal, and EphB4 has been shown to be associated with cancer malignancy. Although there have been reports on the relationship between EphB4 signaling and glioblastoma in intracranial tumors, but the number of studies on ependymomas has been limited. Through this study, we were able to examine the expression of EphB4 receptor in ependymomas using surgical specimens for the first time and elucidate its role from a molecular biological perspective. In the future, we are confident that we will be able to discover the possibility of a new treatment for ependymoma by inhibiting EphB4 and contribute to the formation of the basis for drug treatment of ependymoma.

Free Research Field

脳腫瘍病理

Academic Significance and Societal Importance of the Research Achievements

本プロジェクトの遂行手法は手術材料、培養細胞（タンパク、mRNA、蛍光二重染色、細胞ライブイメージングを含む）など多方面からのアプローチであり、組織から分子レベルまで及んだ申請者の豊富な経験を基に成立した最新技術・アイデアなどは、基礎実験から多数の臨床検体を用いた多面的な研究である。本研究成果は、未だ最適な化学療法が確立していない上衣腫の治療の発展に大きく貢献するものと期待される。分子標的治療は新たな治療手段として、難治性上衣腫や放射線治療および化学療法に低感度なケースにもっとも有効な治療結果をもたらすと考えられる。