2023 Fiscal Year Final Research Report
Development of MEP with pudendal nerve stimulation during pediatric neurosurgery
| Project/Area Number |
21K09185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56010:Neurosurgery-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田村 健太郎 奈良県立医科大学, 医学部, 講師 (00423913)
高谷 恒範 奈良県立医科大学, 医学部, 助教 (00736506)
中瀬 裕之 奈良県立医科大学, 医学部, 研究員 (10217739)
川口 昌彦 奈良県立医科大学, 医学部, 教授 (60275328)
朴 永銖 奈良県立医科大学, 医学部, 病院教授 (80364066)
佐々木 亮太 奈良県立医科大学, 医学部, 医員 (50896628)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 術中神経モニタリング / 運動誘発電位 / 顔面神経 / 三叉神経 / テタヌス刺激 |
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| Outline of Final Research Achievements |
The intraoperative motor evoked potentials (MEPs) in pediatric craniotomy is challenging because of its low detection rate, which makes it unreliable. The authors investigated the effects of MEP amplification following tetanic stimulation of the pudendal nerve in pediatric patients undergoing craniotomy.During surgery motor evoked potential were elicited for 15 patients less than 15 years of age undergoing craniotomy. Compound muscle action potentials of upper and lower extremities were compared between with tetanic stimulation to the pudendal nerve and without. As a result, the identification and amplitude increase rates were significantly higher in the group of MEP with tetanic stimulation than without.In pediatric craniotomy, the authors observed the amplification effect of MEPs with pudendal nerve tetanic stimulation. These findings suggested the likelihood of more reliable intraoperative MEP monitoring in pediatric cases.
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| Free Research Field |
脳神経外科
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| Academic Significance and Societal Importance of the Research Achievements |
小児脳神経外科において導出することすら困難であった術中MEPが安定してモニタリングできる可能性が高くなった。この研究成果によって小児脳神経外科手術の安全性を高める術中MEPモニタリングの信頼性と有用性が高くなったと考えられる。
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