Discovery of novel signals related to enthesitis and bone formation in spondyloarthritis and their therapeutic application.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Gifu University
• Principal Investigator: Tanaka Ryo 岐阜大学, 大学院医学系研究科, 招へい教員 (70422722)
• Co-Investigator(Kenkyū-buntansha): 河村 真吾 岐阜大学, 医学部附属病院, 助教 (30456511) ; 秋山 治彦 岐阜大学, 大学院医学系研究科, 教授 (60402830)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 脊椎関節炎 / 付着部炎 / 脊椎関節炎モデルマウス

Outline of Final Research Achievements

We purified proteoglycan based on the protocol described in the previous paper, and administered the purified proteoglycan to mice in accordance with the previous report to create a mouse model of spondyloarthritis. Ten weeks after the first administration, tissue specimens were prepared from the mouse hind limbs and subjected to histological analysis, but no Achilles tendonitis or arthritis had occurred as previously reported. We repeated the experiment, but were unable to reproduce the creation of a proteoglycan-induced SpA model, and therefore abandoned the research.

Free Research Field

整形外科学

Academic Significance and Societal Importance of the Research Achievements

本研究で作成した脊椎関節炎モデルマウスでは付着部炎や関節炎の発生が認めらなかったため、本モデルマウスでの付着部炎と骨新生の関連についての解析や、関連する分子または細胞内シグナルの解析は行えなかった。