Pathomechanism of painful fracture nonunion

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09252
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Kochi University
• Principal Investigator: Ikeuchi Masahiko 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00372730)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 偽関節 / 骨折 / 疼痛

Outline of Final Research Achievements

We established a novel rat model of nonunion fracture with different stability. Dynamic weight bearing test showed that fracture site stability greatly affected the pain behavior. CGRP positive neurons were upregulated in the L3 DRG in this model, which partially explains the pathomechanism of painful fracture nonunion.

Free Research Field

運動器疼痛

Academic Significance and Societal Importance of the Research Achievements

社会の高齢化とともに骨折後の偽関節患者は増加の一途をたどっており、臨床の現場では、有痛性であっても偽関節手術を行えない虚弱な高齢者の存在が切実な問題となっている。有痛性偽関節の疼痛発生機序を解明できれば、手術に代わる新たな治療法の開発につながる。