2023 Fiscal Year Final Research Report
Search for prognostic molecular markers in terminal stage of cancer patients
| Project/Area Number |
21K09253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
前田 真吾 鹿児島大学, 医歯学総合研究科, 特任教授 (60353463)
佐々木 裕美 鹿児島大学, 医歯学域鹿児島大学病院, 講師 (60773380)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | terminal stage of cancer / bone metastasis / prognostic prediction |
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| Outline of Final Research Achievements |
We initiated this study based on the idea that a quantifiable molecular marker that changes universally in terminally ill patients would be a very useful objective prognostic tool for providing appropriate treatment to patients with bone metastases from cancer, regardless of the nature of the treatment, such as molecular targeted therapy.
Blood samples were collected from patients with metastatic bone tumors visiting our bone metastasis outpatient clinic and submitted to proteomic analysis. The analysis identified five molecules whose expression changed significantly in patients with a prognosis of 3 months or less compared to those with a prognosis of 6 months or more, and whose expression changed significantly compared to samples from non-cancer patients (t-test p<0.01). Further analysis of these molecules is planned.
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| Free Research Field |
orthopaedic surgery
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| Academic Significance and Societal Importance of the Research Achievements |
骨転移癌患者において、予後不良を予測しうる可能性のある分子を５つ確認することができた。５つの分子ともに癌の進行度に関連するとの報告があり、さらなる追試にて予後予測マーカーとして実臨床でも使用できる可能性が示唆される。特に１つの分子は骨代謝においても関連が報告されており、今まで報告のない骨転移に普遍的に使用できるマーカーの可能性がある
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