2023 Fiscal Year Final Research Report

Elucidation of the mechanisms underlying the onset of benign prostatic hyperplasia focusing on the prostate microbiome and application to personalized medicine

Research Project

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Project/Area Number	21K09344
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56030:Urology-related
Research Institution	Osaka University
Principal Investigator	Takezawa Kentaro 大阪大学, 大学院医学系研究科, 助教 (90648015)
Co-Investigator(Kenkyū-buntansha)	島田昌一大阪大学, 大学院医学系研究科, 教授 (20216063) 福原慎一郎大阪大学, 大学院医学系研究科, 准教授 (20609870) 小山佳久大阪大学, 大学院医学系研究科, 助教 (40397667) 木内寛大阪大学, 大学院医学系研究科, 招へい教員 (70403053)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	前立腺肥大症
Outline of Final Research Achievements	In this study, we aimed to elucidate the relationship between the prostate microbiome and benign prostatic hyperplasia (BPH) and explore its application to personalized medicine. First, using fluorescence in situ hybridization, we discovered the presence of numerous bacteria within the human prostate glandular ducts. Next, we compared the bacterial flora in prostate tissue between BPH patients and healthy individuals, revealing a reduced diversity of the prostate microbiome in BPH cases. Furthermore, our comparative analysis of bacterial composition highlighted an increased abundance of Burkholderia genus and Burkholderiaceae family bacteria in the prostate microbiome of BPH patients. Based on these findings, it is suggested that the prostate microbiome may play a role in the onset and progression of BPH.
Free Research Field	排尿障害
Academic Significance and Societal Importance of the Research Achievements	【学術的意義】前立腺細菌叢に着目し、前立腺肥大症の予防法や治療法の開発を目指した研究です。前立腺肥大症の患者さんの前立腺細菌叢に特徴があることを明らかにし、前立腺細菌叢が前立腺肥大症の治療ターゲットとなる可能性を明らかにしました。【社会的意義】前立腺肥大症は中高年男性に広く見られる疾患で、頻尿や尿勢低下などの症状を引き起こします。本研究成果は、前立腺肥大症の予防法や新たな薬物治療の開発に繋がり、前立腺肥大症患者さんの生活の質を向上させることが期待されます。