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2023 Fiscal Year Final Research Report

Elucidation of the mechanisms underlying the onset of benign prostatic hyperplasia focusing on the prostate microbiome and application to personalized medicine

Research Project

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Project/Area Number 21K09344
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionOsaka University

Principal Investigator

Takezawa Kentaro  大阪大学, 大学院医学系研究科, 助教 (90648015)

Co-Investigator(Kenkyū-buntansha) 島田 昌一  大阪大学, 大学院医学系研究科, 教授 (20216063)
福原 慎一郎  大阪大学, 大学院医学系研究科, 准教授 (20609870)
小山 佳久  大阪大学, 大学院医学系研究科, 助教 (40397667)
木内 寛  大阪大学, 大学院医学系研究科, 招へい教員 (70403053)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords前立腺肥大症
Outline of Final Research Achievements

In this study, we aimed to elucidate the relationship between the prostate microbiome and benign prostatic hyperplasia (BPH) and explore its application to personalized medicine. First, using fluorescence in situ hybridization, we discovered the presence of numerous bacteria within the human prostate glandular ducts. Next, we compared the bacterial flora in prostate tissue between BPH patients and healthy individuals, revealing a reduced diversity of the prostate microbiome in BPH cases. Furthermore, our comparative analysis of bacterial composition highlighted an increased abundance of Burkholderia genus and Burkholderiaceae family bacteria in the prostate microbiome of BPH patients. Based on these findings, it is suggested that the prostate microbiome may play a role in the onset and progression of BPH.

Free Research Field

排尿障害

Academic Significance and Societal Importance of the Research Achievements

【学術的意義】前立腺細菌叢に着目し、前立腺肥大症の予防法や治療法の開発を目指した研究です。前立腺肥大症の患者さんの前立腺細菌叢に特徴があることを明らかにし、前立腺細菌叢が前立腺肥大症の治療ターゲットとなる可能性を明らかにしました。
【社会的意義】前立腺肥大症は中高年男性に広く見られる疾患で、頻尿や尿勢低下などの症状を引き起こします。本研究成果は、前立腺肥大症の予防法や新たな薬物治療の開発に繋がり、前立腺肥大症患者さんの生活の質を向上させることが期待されます。

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Published: 2025-01-30  

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